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Questions About Lectins

Wheat Lectin Mimics Insulin?


What evidence do you have that wheat interacts with insulin? In my four years of dietetics training I've never seen, heard or read a reference to this.


No problem, here's a few references. There are many more in the online databases such as PUBMED.

Livingston JN, Purvis BJ. Effects of wheat germ agglutinin on insulin binding and insulin sensitivity of fat cells. Am J Physiol. 1980 Mar;238(3):E267-75.

Shemer J, LeRoith D. The interaction of brain insulin receptors with wheat germ agglutinin. Neuropeptides. 1987 Jan;9(1):1-8.

Ponzio G, Debant A, Contreres JO, Rossi B. Wheat-germ agglutinin mimics metabolic effects of insulin without increasing receptor autophosphorylation.Cell Signal 1990;2(4):377-86

Kitano N, Taminato T, Ida T, Seno M, Seino Y, Matsukura S, Kuno S, Imura H. Detection of antibodies against wheat germ agglutinin bound glycoproteins on the islet-cell membrane. Diabet Med. 1988 Mar;5(2):139-44.

Messina JL, Hamlin J, Larner J. Insulin-mimetic actions of wheat germ agglutinin and concanavalin A on specific mRNA levels. Arch Biochem Biophys. 1987 Apr;254(1):110-5.

The Ask Dr. D'Adamo internet advice column ran from 1996 to 2009, at which time Dr. D'Adamo's teaching and programming responsibilities no longer allowed him to devote time and resources to directly answering visitor questions. However we've recently reorganized this treasure-trove of material and made it again available to his readership. He occasionally posts new entries. These are marked with a NEW tag.

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