Ask Dr. D'Adamo

Ask Dr. D'Adamo Index    |     Latest Entry    |     Pull a Random Question

Questions About Lectins

Mistletoe Lectin As Cancer Therapy


STUDY:
Lectins isolated from Korean mistletoe (Viscum album coloratum) induce apoptosis in tumor cells.

JOURNAL:
Cancer Lett 1999 Feb 8;136(1):33-40

AUTHORS:
Yoon TJ, Yoo YC, Kang TB, Shimazaki K, Song SK, Lee KH, Kim SH, Park CH, Azuma I, Kim JB.

ABSTRACT:
Cytotoxic lectins (KML-C) were isolated from an extract of Korean mistletoe [Viscum album C.] and the chemical and biological properties of KML-C were examined, partly by comparing them with a lectin (EML-1) from European mistletoe[Viscum album L. (loranthaceae)]. The hemagglutinating activity of KML-C was inhibited by N-acetyl-D-galactosamine and D-galactose. The isolated lectins showed strong cytotoxicity against various human and murine tumor cells. Tumor cells treated with KML-C exhibited typical patterns of apoptotic cell death, such as apparent morphological changes and DNA fragmentation, and its apoptosis-inducing activity was blocked by addition of Zn2+, an inhibitor of Ca2+/Mg2+ -dependent endonucleases, in a dose-dependent manner. These results suggest that KML-C is a novel lectin related to the cytotoxicity of Korean mistletoe, and that its cytotoxic activity against tumor cells is due to apoptosis mediated by Ca2+/Mg2+ -dependent endonucleases.



COMMENTARY:
Misteltoe is a traditional plant medicine for cancer treatment, widely used in Europe. Recently, studies have determined that the presumed anti-cancer component in mistletoe may in fact be the powerful lectin contained in the plant. This study is important as it help elaborate the mechanism by which mistletoe lectin may be an important anti-cancer drug: The study indicates that programmed cell death (apoptosis) is activated by the ability of the lectin to disrupt the action of enzymes involved with the transport of calcium and magnesium into the cell's nucleus.









The Ask Dr. D'Adamo internet advice column ran from 1996 to 2009, at which time Dr. D'Adamo's teaching and programming responsibilities no longer allowed him to devote time and resources to directly answering visitor questions. However we've recently reorganized this treasure-trove of material and made it again available to his readership. He occasionally posts new entries. These are marked with a NEW tag.



facebook share    Tweet This!


SPOTLIGHT

GENOMA SECURITY


Dr. Peter D'Adamo, author of Eat Right 4 Your Type, developed Genoma Security to help your immune system work at peak efficiency. It is comprised of a traditional blend of well-researched herbal ingredients designed to support a healthy immune response.

Click to learn more

Click the Play button to hear to Dr. Peter J. D'Adamo discuss .



The statements made on our websites have not been evaluated by the FDA (U.S. Food & Drug Administration).
Our products and services are not intended to diagnose, cure or prevent any disease. If a condition persists, please contact your physician.
Copyright © 2015-2020, Hoop-A-Joop, LLC, Inc. All Rights Reserved.     Log In