Ask Dr. D'AdamoAsk Dr. D'Adamo Index | Latest Entry | Pull a Random Question |
Questions of A More Technical NatureRare Bird Indeed!QUESTION Dear Dr D'Adamo, I am a B+ and have been "eating right" for about 5 weeks and loving it. I am trying to recover from Chronic Fatigue Syndrome and this diet has become an extremely significant part of my "recovery plan". But I write today with a different issue. I have just received results as to secretor status (yes I am one!) and also Lewis blood type. I am Lewis a+b+. I am intrigued and want to know more about this apparently rare type, but cannot find any further information. ANSWER The synthesis of the Lewis antigens is dependent on the interaction of two different enzymes (fucosyltransferases) that are the products of two different genes: 1. The FUT2 or the secretor (Se) gene locus (part of the synthesis of the H blood group antigen) that encodes FUT2 enzyme 2. The FUT3 gene locus which encodes an additional fucosyltransferase enzyme called FUT3. Your final Lewis status is the result of the sequential action of these two enzymes. A simplified description would be that FUT3 codes precursor substance into the 'Lewis a' antigen. This is then acted on by the FUT2 enzyme which converts all the 'Lewis a' antigen into to 'Lewis b'. Thus the genetic basis for secretor STATUS |
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