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Less Oils and Fats For Non-Secretors


Why do type O non secretors have guidelines for less oil than secretors? What is it about being a non secretor that makes us less capable of handling oil?


ABH non-secretors have lower levels of fat-busting enzymes (intestinal alklaine phosphatase) than ABH secretors. They also have lower levels of a variety of lipases (more fat busters) and brush border hydroxlases (again, involved in the transfer of fats broken down in the intestine into the lymphatics.)

Independent of ABO blood group, ABH non-secretors have lower alkaline phosphatase activity than ABH secretors. It has been estimated that the serum alkaline phosphatase activity of non-secretors is only about 20% of the activity in the secretor groups. (1-4)

The intestinal component of alkaline phosphatase is involved with both the breakdown of dietary cholesterol and the absorption of calcium. The differences in intestinal alkaline phosphatase are almost exclusively related to one fraction of the intestinal alkaline phosphatase. Normal molecular mass intestinal alkaline phosphatase (NIAP) is present in the serum of both secretors and non-secretors regardless of ABO blood group. However, the high molecular mass intestinal alkaline phosphatase only appears in serum of Lewis (a-b+) blood group secretors. (5)

1. Domar U, Hirano K, Stigbrand T. Serum levels of human alkaline phosphatase isozymes in relation to blood groups. Clin Chim Acta 1991 Dec 16;203(2-3):305-13

2. Mehta NJ, Rege DV, Kulkarni MB. Total serum alkaline phosphatase (SAP) and serum cholesterol in relation to secretor status and blood groups in myocardial infarction patients. Indian Heart J 1989 Mar;41(2):82-85

3. Tibi L, Collier A, Patrick AW, et al. Plasma alkaline phosphatase isoenzymes in diabetes mellitus. Clin Chim Acta 1988 Oct 14;177(2):147-155

4. Agbedana EO, Yeldu MH. Serum total, heat and urea stable alkaline phosphatase activities in relation to ABO blood groups and secretor phenotypes. Afr J Med Med Sci 1996 Dec;25(4):327-9

5. Matsushita M, Irino T, Stigbrand T, et al. Changes in intestinal alkaline phosphatase isoforms in healthy subjects bearing the blood group secretor and non-secretor. Clin Chim Acta 1998 Sep 14;277(1):13-24

The Ask Dr. D'Adamo internet advice column ran from 1996 to 2009, at which time Dr. D'Adamo's teaching and programming responsibilities no longer allowed him to devote time and resources to directly answering visitor questions. However we've recently reorganized this treasure-trove of material and made it again available to his readership. He occasionally posts new entries. These are marked with a NEW tag.

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