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Questions About Natural Products

I3C and DIM


Along with my Type A diet, A Lifestyle, my snail lectins, calcium d glucorate, aromastat, etc. etc. for breast cancer recurrence protection, I have noticed a battle going on between the makers of I3C and DIM. One accuses the other of making aromatase enzymne increase which of course I don't want to do. Each says their product type is better? Trying to understand the physiology and get through their research both quoting medical journals. It is confusing. What is a girl to do?


Indole-3-carbinol is a phytochemical found in cruciferous vegetables such as cabbage. It shows great potential in preventing cancer, especially hormone-related cancers such as breast and prostate.

DIM (3,3'-Diindolylmethane)is formed naturally when I3C is broken down in the gut. So from I3C you get DIM (although from I3C you also get many other molecules as well.)

DIM is being heavily promoted in the 'longevity' magazines by one doctor, who has a patent on the ability to increase its absorption via the gut (tweaking DIM with d-alpha-tocopheryl polyethylene glycol-1000 succinate to make it absorbable.)

My completely subjective analysis:

1. I3C is more 'food like.'

2. I3C breaks down into many other compounds besides DIM, some of which may be more useful than DIM

3. The studies on DIM itself are not as compelling.


Supplement or stress dietary I3C over any claims about DIM's greater efficacy.

The Ask Dr. D'Adamo internet advice column ran from 1996 to 2009, at which time Dr. D'Adamo's teaching and programming responsibilities no longer allowed him to devote time and resources to directly answering visitor questions. However we've recently reorganized this treasure-trove of material and made it again available to his readership. He occasionally posts new entries. These are marked with a NEW tag.

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