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Questions About Lectins

Lectins and Drug Targeting

Targeted delivery of drugs to the gastrointestinal tract.

Crit Rev Ther Drug Carrier Syst 2001;18(4):341-86

Lavelle EC.

The oral route is attractive for drug administration because it is associated with patient acceptability, less stringent production conditions, and lower costs. However, gastrointestinal destruction of labile molecules and low levels of absorption generally render oral delivery of peptides and proteins ineffective. Several strategies have the potential to enhance the efficacy of orally administered drugs. Bioadhesion is an approach for increasing interaction between drugs and the mucosae. Bioadhesive systems can be nonspecific, achieving adhesion via mechanical processes or specific systems that recognize receptors on epithelial cells. Lectins are one group of specific bioadhesives with many suitable properties for targeting of cells in the gastrointestinal tract (GIT). This review assesses the potential of lectins in the delivery of drugs and vaccines to the GIT.

Targeted drug delivery by binding the drug to any number of different lectins is a 'hot' area in pharmacology these days, since many lectins are 'endocytosed' (actively transported into the intestinal cells), which makes them able to carry durgs they are binded to along in with them.

Good thing this researcher has never read any of the criticisms of my theory by the dieticians from American Dietetic Association and Centers For Science in the Public Interest, since both have asserted that lectins don't penetrate the digestive tract!

The Ask Dr. D'Adamo internet advice column ran from 1996 to 2009, at which time Dr. D'Adamo's teaching and programming responsibilities no longer allowed him to devote time and resources to directly answering visitor questions. However we've recently reorganized this treasure-trove of material and made it again available to his readership. He occasionally posts new entries. These are marked with a NEW tag.

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