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Questions About Natural Products

Quercetin For Prostatitis


STUDY:
Quercetin in men with category III chronic prostatitis: a preliminary prospective, double-blind, placebo-controlled trial.

JOURNAL:
Urology 1999 Dec;54(6):960-3

AUTHORS:
Shoskes DA, Zeitlin SI, Shahed A, Rajfer J.

ABSTRACT:
OBJECTIVES: The National Institutes of Health (NIH) category III chronic prostatitis syndromes (nonbacterial chronic prostatitis and prostatodynia) are common disorders with few effective therapies. Bioflavonoids have recently been shown in an open-label study to improve the symptoms of these disorders in a significant proportion of men. The aim of this study was to confirm these findings in a prospective randomized, double-blind, placebo-controlled trial. METHODS: Thirty men with category IIIa and IIIb chronic pelvic pain syndrome were randomized in a double-blind fashion to receive either placebo or the bioflavonoid quercetin 500 mg twice daily for 1 month. The NIH chronic prostatitis symptom score was used to grade symptoms and the quality-of-life impact at the start and conclusion of the study. RESULTS: Both the quercetin and placebo groups were similar in age, symptom duration, and initial symptom score. Patients taking placebo had a mean improvement in NIH symptom score from 20.2 to 18.8 (not significant), while those taking the bioflavonoid had a mean improvement from 21.0 to 13.1 (P = 0.003). Twenty percent of patients taking placebo and 67% of patients taking the bioflavonoid had an improvement of symptoms of at least 25%. In the 17 patients who received quercetin in the open-label study, 82% had at least a 25% improvement in symptom score. CONCLUSIONS: Therapy with the bioflavonoid quercetin is well tolerated and provides significant symptomatic improvement in most men with chronic pelvic pain syndrome.



COMMENTARY:
Chronic prostatitis is a troublesome condition that can be difficult to control. Typically, long term antibiotics (doxycycline) are considered the only effective treatment (curiously, not because of their anti-microbial effects, but rather because of their probable anti-inflammatory effect). Quercetin is available in many forms and may offer a safe and effective means for many men to control this painful problem.









The Ask Dr. D'Adamo internet advice column ran from 1996 to 2009, at which time Dr. D'Adamo's teaching and programming responsibilities no longer allowed him to devote time and resources to directly answering visitor questions. However we've recently reorganized this treasure-trove of material and made it again available to his readership. He occasionally posts new entries. These are marked with a NEW tag.



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