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Blood Groups and Epilepsy


Is there any known correlation between blood types and epilepsy?


There are a few studies linking blood groups and epilepsy, though the most striking association is not with ABO, but rather the MNS system, where it was found that one marker, the SS variant (Ss/ss/SS) showed a statistically highly significant difference (p below 0.001) in the epileptic patients compared with a control group.(1) A separate study showed a deficiency of blood group AB in the total population of epileptics (2).

There are several studies (3,4) indicating a higher rate of epilepsy in children that are the result of mother-fetus ABO incompatibility (where the fetus possesses a blood type antigen that the mother carries an antibody to). This tends to confirm my suspicion that the most important time to be eating right for your blood type is during pregnancy.

1. Tills D, Warlow A, Richens A, Laidlaw J. Genetic markers in epilepsy: a survey.Hum Hered 1981;31(1):19-31

2. Darbinian VZh, Nersisian VM, Musazlian NO, Maretirosian IG, Akopian LP. [Blood group factor and HLA-related epilepsy among the Armenian population].Zh Nevropatol Psikhiatr Im S S Korsakova 1990;90(9):85-7

3. Nazarow K. [Nervous and mental disorders in cases of immunologic incompatibility within ABO groups]. Neurol Neurochir Pol. 1969 May-Jun;3(3):385-8.

4. Nazarov KN. [On the pathogenesis of the neuropsychiatric sequelae of ABO incompatibility between mother and fetus]. Zh Nevropatol Psikhiatr Im S S Korsakova. 1968;68(10):1488-92.

The Ask Dr. D'Adamo internet advice column ran from 1996 to 2009, at which time Dr. D'Adamo's teaching and programming responsibilities no longer allowed him to devote time and resources to directly answering visitor questions. However we've recently reorganized this treasure-trove of material and made it again available to his readership. He occasionally posts new entries. These are marked with a NEW tag.

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