Interleukin-4 (IL-4)

Immunology?

See Also

• Dietary lectins can induce in vitro release of IL-4 and IL-13 from human basophils
• Atopy?
• IgE

Description

Interleukin-4 (IL-4) Induces B cell proliferation, eosinophil and mast cell growth and function, and IgE expression on B cells. Allergic individuals have a greater propensity to produce IL-4. Many dietary lectins induce the activation of IL-4, which implies that for many people the allergic reaction to dietary lectins may be more important than their agglutinating abilities

Discussion

One of the main immune system [Growth Factors]?. IL4 is a [cytokines? cytokine] produced by T cells that regulates proliferation and differentiation of a variety of cells. It modulates the activity of these cells following binding to cell surface receptors. The amino acid sequence of its extracellular domain defined it as a member of the hematopoietin receptor superfamily.

Polymorphism are associated with resistance to atopy? and progression of AIDS symptomatology. Soriano et al. (2005) determined that the V50 allele predominated in HIV-positive long-term nonprogressors (LTNPs), whereas the I50 allele predominated in healthy controls, typical progressors, and those at risk for infection due to sexual exposure or treatment of hemophilia. Homozygosity for V50 was increased in LTNPs compared with other groups. Soriano et al. (1) concluded that V50 homozygosity appears to be associated with slow progression to AIDS after HIV infection.

Links

• OMIN Entry for IL-4 Receptor

References