Difference (from prior minor revision)
> * [[INSIG2 (Insulin Induced Gene 2)]]
C O N T E N T S
UCP1 uncoupling protein 1 (mitochondrial, proton carrier) [Homo sapiens]
Summary: Mitochondrial uncoupling proteins (UCP) are members of the family of mitochondrial anion carrier proteins (MACP). UCPs separate oxidative phosphorylation from ATP synthesis with energy dissipated as heat, also referred to as the mitochondrial proton leak. UCPs facilitate the transfer of anions from the inner to the outer mitochondrial membrane and the return transfer of protons from the outer to the inner mitochondrial membrane. They also reduce the mitochondrial membrane potential in mammalian cells. Tissue specificity occurs for the different UCPs and the exact methods of how UCPs transfer H+/OH- are not known. UCPs contain the three homologous protein domains of MACPs. This gene is expressed only in brown adipose tissue, a specialized tissue which functions to produce heat.
Additive effect of A-->G (-3826) variant of the uncoupling protein gene and the Trp64Arg mutation of the beta 3-adrenergic receptor gene on weight gain in morbid obesity.
Int J Obes Relat Metab Disord. 1996 Dec;20(12):1062-6. Clement K, Ruiz J, Cassard-Doulcier AM, Bouillaud F, Ricquier D, Basdevant A, Guy-Grand B, Froguel P.
UCP1 is essential for adaptive adrenergic nonshivering thermogenesis
Am J Physiol Endocrinol Metab. 2006 Apr 4; Golozoubova V, Cannon B, Nedergaard J.
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