{"id":601,"date":"2020-03-18T09:29:19","date_gmt":"2020-03-18T09:29:19","guid":{"rendered":"https:\/\/dadamo.com\/dangerous\/?p=601"},"modified":"2020-03-20T12:41:20","modified_gmt":"2020-03-20T12:41:20","slug":"should-i-worry-about-my-supplements-triggering-a-cytokine-storm","status":"publish","type":"post","link":"https:\/\/dadamo.com\/dangerous\/2020\/03\/18\/should-i-worry-about-my-supplements-triggering-a-cytokine-storm\/","title":{"rendered":"Covid-19: Should I worry about my supplements triggering a cytokine storm?"},"content":{"rendered":"<p>Covid19: 03\/19\/2020<\/p>\n<p>No.<\/p>\n<p>We need to stop worrying about an herb or vitamin triggering a &#8216;cytokine storm,&#8217; (CS) a massive immunologic overreaction that is seen at the end stage of certain viral infections. Most of the time CS is not triggered by the virus but rather another end-stage consequence, septic shock, and with it, multiple organ failure.<\/p>\n<p>Septic shock is triggered by molecules known as TLRs (toll-like receptors) that are usually activated in response to bacterial toxins known as lipopolysaccharides (LPS).<\/p>\n<p>Activation of TLR leads to the production of &#8216;inflamasomes&#8217; (principally one known as NLRP3), which then trigger the release of cytokines. NLRP3 is inhibited by nitric oxide (NO) a small signaling molecule produced by virtually every cell in the body.<\/p>\n<p>Matter of fact, you might have benefited from elderberry, since it has been shown to enhance NO blockage of inflammasome activity and actually suppress TLR4. Dark pigmented fruits have been known to block LPS activation of inflammasomes for decades.<\/p>\n<p>So let&#8217;s get things straight. This is man-bites-dog stuff. If you&#8217;re headed for this type of consequence, a cytokine storm preceded by septic shock, I can assure you they we need not worry about the elderberry you&#8217;ve taken. In fact PubMed shows zero studies when &#8216;elderberry&#8217; and &#8216;cytokine storm&#8217; are entered as search terms. Zero. It&#8217;s the equivalent of waiting for a commuter train, seeing a brown bag lunch on the track and worrying that it might potentially derail your ride.<\/p>\n<p>I&#8217;ll put it in even simpler terms, virtually all rational natural therapies for Covid19 are not potent enough to do this level of harm. If they did, that would be bad, but then again we&#8217;d have some really great new drugs for a slew of other human ailments, like cancer.<\/p>\n<ul>\n<li><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/25415606?\">Anti-inflammatory activity of fruit fractions in vitro, mediated through toll-like receptor 4 and 2 in the context of inflammatory bowel disease.<\/a><\/li>\n<\/ul>\n<p><A href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC3899428\/?\">I posted this article on FaceBook  while back<\/a> but since I now endlessly have to deal with assertions that elderberry will put you on a ventilator with an out of control cytokine storm I thought I&#8217;d share it again. Turns out elderberry is directly lethal to coronavirus. In all fairness, it was studied in chickens, and the type of coronavirus was the gamma form (Covid-19 is the beta form). But in reading the entire article I could find no evidence that a single chicken went into cytokine storm after being administered elderberry.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Covid19: 03\/19\/2020 No. We need to stop worrying about an herb or vitamin triggering a &#8216;cytokine storm,&#8217; (CS) a massive immunologic overreaction that is seen at the end stage of certain viral infections. Most of the time CS is not triggered by the virus but rather another end-stage consequence, septic shock, and with it, multiple<\/p>\n<p><a href=\"https:\/\/dadamo.com\/dangerous\/2020\/03\/18\/should-i-worry-about-my-supplements-triggering-a-cytokine-storm\/\" class=\"more-link themebutton\">Read More<\/a><\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"spay_email":"","jetpack_publicize_message":"","jetpack_is_tweetstorm":false},"categories":[11,23],"tags":[],"jetpack_featured_media_url":"","jetpack_publicize_connections":[],"jetpack_sharing_enabled":true,"jetpack_shortlink":"https:\/\/wp.me\/paaqQX-9H","jetpack-related-posts":[{"id":674,"url":"https:\/\/dadamo.com\/dangerous\/2020\/03\/23\/covid-19-a-few-caveats-and-a-bit-of-optimism\/","url_meta":{"origin":601,"position":0},"title":"Covid-19:  A few caveats and a bit of optimism","date":"March 23, 2020","format":false,"excerpt":"A few caveats. There are helpful people and communities with trustworthy suggestions and advice. And then are other 'experts' who just have to tell the audience inside a theatre that's on fire exactly where they think the exit doors are, even though they don't actually know where the exit doors\u2026","rel":"","context":"In &quot;Covid19&quot;","img":{"alt_text":"","src":"https:\/\/i1.wp.com\/dadamo.com\/dangerous\/wp-content\/uploads\/2020\/03\/compassion.jpg?fit=1024%2C440&ssl=1&resize=350%2C200","width":350,"height":200},"classes":[]},{"id":719,"url":"https:\/\/dadamo.com\/dangerous\/2020\/04\/01\/covid-19-melatonin\/","url_meta":{"origin":601,"position":1},"title":"Covid-19: Melatonin","date":"April 1, 2020","format":false,"excerpt":"Most of us have heard of, or even occasionally used the supplement melatonin. It is the most popular over-the-counter sleep remedy in the US, resulting in sales in excess of US $400 million during 2017. Melatonin is a hormone that is primarily released by the pineal gland in the brain\u2026","rel":"","context":"In &quot;Covid19&quot;","img":{"alt_text":"","src":"https:\/\/i0.wp.com\/dadamo.com\/dangerous\/wp-content\/uploads\/2020\/04\/sleep.jpg?fit=800%2C547&ssl=1&resize=350%2C200","width":350,"height":200},"classes":[]},{"id":628,"url":"https:\/\/dadamo.com\/dangerous\/2020\/03\/04\/covid-19-pool-shock\/","url_meta":{"origin":601,"position":2},"title":"Covid-19 : Pool Shock","date":"March 4, 2020","format":false,"excerpt":"03\/04\/2020: Pool Shock If you've been reading my posts over the last few weeks, you'll have noticed I recommend 'pool shock' granules over liquid bleach as a surface disinfectant. Many online vendors sell , as do pool and hot tub supply stores. Pool shock is comparable to bleach when following\u2026","rel":"","context":"In &quot;Covid19&quot;","img":{"alt_text":"","src":"","width":0,"height":0},"classes":[]},{"id":605,"url":"https:\/\/dadamo.com\/dangerous\/2020\/03\/14\/covid19-why-older-people-get-hit-harder\/","url_meta":{"origin":601,"position":3},"title":"Covid-19:  Why older people get hit harder","date":"March 14, 2020","format":false,"excerpt":"I've heard again and again about how the reason that older people are more impacted by Covid19 is due to their diminished immune system capacity. This seemed from the start to make little sense to me. I mean, if their immune systems were degraded, they'd have less acute inflammation as\u2026","rel":"","context":"In &quot;Covid19&quot;","img":{"alt_text":"","src":"https:\/\/i0.wp.com\/dadamo.com\/dangerous\/wp-content\/uploads\/2020\/03\/old.jpg?fit=1200%2C800&ssl=1&resize=350%2C200","width":350,"height":200},"classes":[]},{"id":616,"url":"https:\/\/dadamo.com\/dangerous\/2020\/03\/11\/covid-19-should-you-take-nsaids\/","url_meta":{"origin":601,"position":4},"title":"Covid-19: Should you take NSAIDS?","date":"March 11, 2020","format":false,"excerpt":"People have asked me about the risk of using NSAIDS like ibuprofen (Advil), for inflammation and fever, in situations such as Covid19. There is really two sides to the answer. NSAIDs like ibuprofen could increase levels of ACE2 (shown in animal models, but not in patients.) Most medical professional societies\u2026","rel":"","context":"In &quot;Covid19&quot;","img":{"alt_text":"","src":"","width":0,"height":0},"classes":[]},{"id":596,"url":"https:\/\/dadamo.com\/dangerous\/2020\/03\/19\/pioneering\/","url_meta":{"origin":601,"position":5},"title":"Covid-19: Pioneering","date":"March 19, 2020","format":false,"excerpt":"On a recent thread a practitioner on my Facebook Group wrote about their anxiety and frustration in attempting to help an elderly friend from a distance. They wrote of their own fear and uncertainty and the overall lack of any guidance whatsoever with regard to just how to take care\u2026","rel":"","context":"In &quot;Covid19&quot;","img":{"alt_text":"","src":"https:\/\/i2.wp.com\/dadamo.com\/dangerous\/wp-content\/uploads\/2020\/03\/frederic-schreyer-and-family-1024.jpg?fit=1024%2C795&ssl=1&resize=350%2C200","width":350,"height":200},"classes":[]}],"_links":{"self":[{"href":"https:\/\/dadamo.com\/dangerous\/wp-json\/wp\/v2\/posts\/601"}],"collection":[{"href":"https:\/\/dadamo.com\/dangerous\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/dadamo.com\/dangerous\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/dadamo.com\/dangerous\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/dadamo.com\/dangerous\/wp-json\/wp\/v2\/comments?post=601"}],"version-history":[{"count":4,"href":"https:\/\/dadamo.com\/dangerous\/wp-json\/wp\/v2\/posts\/601\/revisions"}],"predecessor-version":[{"id":663,"href":"https:\/\/dadamo.com\/dangerous\/wp-json\/wp\/v2\/posts\/601\/revisions\/663"}],"wp:attachment":[{"href":"https:\/\/dadamo.com\/dangerous\/wp-json\/wp\/v2\/media?parent=601"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/dadamo.com\/dangerous\/wp-json\/wp\/v2\/categories?post=601"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/dadamo.com\/dangerous\/wp-json\/wp\/v2\/tags?post=601"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}