{"id":636,"date":"2020-02-09T20:55:43","date_gmt":"2020-02-09T20:55:43","guid":{"rendered":"https:\/\/dadamo.com\/dangerous\/?p=636"},"modified":"2020-03-19T20:57:49","modified_gmt":"2020-03-19T20:57:49","slug":"covid-19-and-in-todays-bad-news","status":"publish","type":"post","link":"https:\/\/dadamo.com\/dangerous\/2020\/02\/09\/covid-19-and-in-todays-bad-news\/","title":{"rendered":"Covid-19: And in today’s bad news.."},"content":{"rendered":"

CoVD2019: 02\/09\/2020<\/p>\n

And in today’s bad news.<\/strong><\/p>\n

‘Initially, the basic reproductive number, R0, was estimated to be 2.2 to 2.7. Here we provide a new estimate of this quantity… Integrating these estimates and high-resolution real-time human travel and infection data with mathematical models, we estimated that the number of infected individuals during early epidemic double every 2.4 days, and the R0 value is likely to be between 4.7 and 6.6.’ Note: This is a pre-pub, non-peer-reviewed report.<\/p>\n

Article Link<\/a><\/p>\n

Polymorphisms in ACE2 don’t seem to influence ARDS.<\/strong><\/p>\n

‘We therefore conclude that although ACE2 serves functionally as the receptor for entry of the SARS coronavirus into human host cells, the evidence provided by this study does not support an association between its common genetic variants and SARS susceptibility or outcome. Despite its X-chromosome location, poor outcomes in male SARS patients do not appear to be related to genetic variants of ACE2.’<\/p>\n

Eyes are on Singapore.<\/strong><\/p>\n

Singapore appears to have sustained community transmission of coronavirus and may be 3-4 weeks ahead of what could unfold in U.S. Both nations should have similar number of imported cases, but Singapore density will make spread manifest more quickly. It\u2019s deeply concerning that of the cases identified in Singapore, as of Sunday (02\/09\/2020) night, six patients are in intensive care. These are patients of different ages, and not just the older ones. Singapore has sustained community transmission despite most capable government on planet, best healthcare system on planet, and warm weather (high 80s to low 90s Fahrenheit this week).Singapore raised its ‘Disease Outbreak Response System Condition’ to orange last week – which means the disease is severe and spreads easily from person to person.<\/p>\n

How to wash your hands<\/strong>.<\/p>\n

Use warm water, a good soap and a rotational movement, sort of like when a movie villain is happy about something. My old microbiology teacher used to tell us to wash long enough to sing “Happy Birthday’ to ourselves twice. <\/p>\n

Keep toilet covers down.<\/p>\n

During the SARS crisis #SARS in Hong Kong many people in a condo tower got infected. Turned out plumbing caused toilets to expel ‘air’ back into apartments, cross-contaminating one after another. <\/p>\n

<\/p>\n","protected":false},"excerpt":{"rendered":"

CoVD2019: 02\/09\/2020 And in today’s bad news. ‘Initially, the basic reproductive number, R0, was estimated to be 2.2 to 2.7. Here we provide a new estimate of this quantity… Integrating these estimates and high-resolution real-time human travel and infection data with mathematical models, we estimated that the number of infected individuals during early epidemic double<\/p>\n

Read More<\/a><\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"spay_email":"","jetpack_publicize_message":"","jetpack_is_tweetstorm":false},"categories":[23],"tags":[],"jetpack_featured_media_url":"","jetpack_publicize_connections":[],"jetpack_sharing_enabled":true,"jetpack_shortlink":"https:\/\/wp.me\/paaqQX-ag","jetpack-related-posts":[{"id":747,"url":"https:\/\/dadamo.com\/dangerous\/2020\/04\/04\/covid-19-ace2\/","url_meta":{"origin":636,"position":0},"title":"Covid-19: The ACE2 of Spades","date":"April 4, 2020","format":false,"excerpt":"Angiotensin-converting enzyme 2 (ACE2), a protein on the surface of the cell membrane, is now at center-stage in this outbreak as the key receptor for the spike glycoprotein of SARS-CoV-2. ACE2 is part of renin\u2013angiotensin\u2013aldosterone system (RAAS) is an elegant cascade of protein linkages that orchestrate key processes in human\u2026","rel":"","context":"In "Bioinformatics"","img":{"alt_text":"","src":"https:\/\/i0.wp.com\/dadamo.com\/dangerous\/wp-content\/uploads\/2020\/04\/barabasi.jpg?fit=640%2C414&ssl=1&resize=350%2C200","width":350,"height":200},"classes":[]},{"id":719,"url":"https:\/\/dadamo.com\/dangerous\/2020\/04\/01\/covid-19-melatonin\/","url_meta":{"origin":636,"position":1},"title":"Covid-19: Melatonin","date":"April 1, 2020","format":false,"excerpt":"Most of us have heard of, or even occasionally used the supplement melatonin. It is the most popular over-the-counter sleep remedy in the US, resulting in sales in excess of US $400 million during 2017. Melatonin is a hormone that is primarily released by the pineal gland in the brain\u2026","rel":"","context":"In "Covid19"","img":{"alt_text":"","src":"https:\/\/i0.wp.com\/dadamo.com\/dangerous\/wp-content\/uploads\/2020\/04\/sleep.jpg?fit=800%2C547&ssl=1&resize=350%2C200","width":350,"height":200},"classes":[]},{"id":616,"url":"https:\/\/dadamo.com\/dangerous\/2020\/03\/11\/covid-19-should-you-take-nsaids\/","url_meta":{"origin":636,"position":2},"title":"Covid-19: Should you take NSAIDS?","date":"March 11, 2020","format":false,"excerpt":"People have asked me about the risk of using NSAIDS like ibuprofen (Advil), for inflammation and fever, in situations such as Covid19. There is really two sides to the answer. NSAIDs like ibuprofen could increase levels of ACE2 (shown in animal models, but not in patients.) Most medical professional societies\u2026","rel":"","context":"In "Covid19"","img":{"alt_text":"","src":"","width":0,"height":0},"classes":[]},{"id":605,"url":"https:\/\/dadamo.com\/dangerous\/2020\/03\/14\/covid19-why-older-people-get-hit-harder\/","url_meta":{"origin":636,"position":3},"title":"Covid-19: Why older people get hit harder","date":"March 14, 2020","format":false,"excerpt":"I've heard again and again about how the reason that older people are more impacted by Covid19 is due to their diminished immune system capacity. This seemed from the start to make little sense to me. I mean, if their immune systems were degraded, they'd have less acute inflammation as\u2026","rel":"","context":"In "Covid19"","img":{"alt_text":"","src":"https:\/\/i0.wp.com\/dadamo.com\/dangerous\/wp-content\/uploads\/2020\/03\/old.jpg?fit=1200%2C800&ssl=1&resize=350%2C200","width":350,"height":200},"classes":[]},{"id":620,"url":"https:\/\/dadamo.com\/dangerous\/2020\/03\/20\/covid-19-blood-type\/","url_meta":{"origin":636,"position":4},"title":"Covid-19: ABO Blood Type","date":"March 20, 2020","format":false,"excerpt":"\u00a0 The media was awash with reports of a preprint (not-peer reviewed) report that individuals who are blood type A might be at more risk of Covid19 infection than those who are type O. The study was conducted by scientists and doctors from cities across China including Beijing, Wuhan, Shanghai\u2026","rel":"","context":"In "Covid19"","img":{"alt_text":"","src":"https:\/\/i1.wp.com\/dadamo.com\/dangerous\/wp-content\/uploads\/2020\/03\/rbc.jpg?fit=958%2C651&ssl=1&resize=350%2C200","width":350,"height":200},"classes":[]},{"id":640,"url":"https:\/\/dadamo.com\/dangerous\/2020\/01\/19\/wuhan-coronavirus-01-19-2020\/","url_meta":{"origin":636,"position":5},"title":"Wuhan Coronavirus: 01\/19\/2020","date":"January 19, 2020","format":false,"excerpt":"Wuhan Coronavirus (1\/25\/2020) Due to the latency of the virus, the effects of the current active public health measures underway, media fatigue, and the extensive (and largely terrible) coverage in the media, an inevitable (and understandable) backlash is the invariable result. Overly facile responses to what some consider 'coronavirus hype'\u2026","rel":"","context":"In "Covid19"","img":{"alt_text":"","src":"","width":0,"height":0},"classes":[]}],"_links":{"self":[{"href":"https:\/\/dadamo.com\/dangerous\/wp-json\/wp\/v2\/posts\/636"}],"collection":[{"href":"https:\/\/dadamo.com\/dangerous\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/dadamo.com\/dangerous\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/dadamo.com\/dangerous\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/dadamo.com\/dangerous\/wp-json\/wp\/v2\/comments?post=636"}],"version-history":[{"count":1,"href":"https:\/\/dadamo.com\/dangerous\/wp-json\/wp\/v2\/posts\/636\/revisions"}],"predecessor-version":[{"id":637,"href":"https:\/\/dadamo.com\/dangerous\/wp-json\/wp\/v2\/posts\/636\/revisions\/637"}],"wp:attachment":[{"href":"https:\/\/dadamo.com\/dangerous\/wp-json\/wp\/v2\/media?parent=636"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/dadamo.com\/dangerous\/wp-json\/wp\/v2\/categories?post=636"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/dadamo.com\/dangerous\/wp-json\/wp\/v2\/tags?post=636"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}