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DR. D'ADAMO: LECSTER 7


The lectin database of Dr. Peter D'Adamo.
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Dolichos biflorus

SPECIES IMAGE
SOURCEHorse gram
LECTINSDBA-S, DBA-R, DB-58, DB-57, DB46
MOLECULAR IMAGE
CLASSLegume lectin
NOMENLECp.Dol.Bif.se.Hga1 (DBA) LECp.Dol.Bif.pl.Hcu1 (DB58) LECp.Dol.Bif.pl.Hcu2 (DB57) LECp.Dol.Bif.ro.?ga1 (DB46)
INDEXPlant lectin / Plant / Seed / Hololectins / Gal/GalNAc-binding lectins
CHARACTERIZATIONFor a characterization of DBA-R, see: Arch Biochem Biophys 1987 Nov 1;258(2):535-44 DBA represents about 10% of the toal soluble seed protein. The other lectins are only mnor proteins.
BIOACTIVITYDBA agglutinates blood group A1 specifically. The carbohydrate binding properties of the Dolichos biflorus seed lectin and DB58, a vegetative tissue lectin from this plant, were compared using two types of solid phase assays. Both lectins bind to hog blood group A + H substance and this binding can be inhibited with free blood group A + H substance. See: Glycoconj J 1994 Oct;11(5):395-9 DBA binds to squamous and adeno cancersof the lungs. See: Cancer 1992 (16G); 103-109
SOURCE TISSUESeed
SPECIFICITYDBA: GalNAc (terminal non-reducing alpha GalNAc; GalNAc alpha (1,3)GalNAc (Forssman antigen) >GalNAc; Cad-antigen; blood group A1 DB58: Complex (unknown) DB57: Complex (unknown) DB46: GalNAc
INHIBITORSalpha-GalNAc
REFERENCESJ Biol Chem. 1975 Apr 10;250(7):2756-62. Biochemistry. 1970 Feb 17;9(4):869-77.
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