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DR. D'ADAMO: LECSTER 7The lectin database of Dr. Peter D'Adamo. BACK TO INDEX | LECSTER7 FAQ |
Agaricus bisporus | |
| SPECIES IMAGE |  | SOURCE | Domestic mushroom |
| LECTINS | ABA-I, ABA-II, ABA-III, ABA-IV |
| MOLECULAR IMAGE |  | CLASS |
| NOMEN | LECf.Aga.Bis.xx.Xga1 |
| INDEX | Lectin from fungi / / / / Gal/GalNAc-binding lectins |
| CHARACTERIZATION | All lectins were found to have quite similar carbohydrate -binding specificities. See: Biol Chem Hoppe Seyler 1985 Mar;366(3):213-21. Lectins from Agaricus bisporus and Agaricus campestris stimulate insulin and glucagon release from isolated rat islets in the presence of 2 mM glucose. In the case of insulin release, maximal stimulation was observed at lectin concentrations above 58 mug. per milliliter (approximately 1 muM). See: Diabetes 1975 Aug;24(8):705-14 For sharacterization of the cell surface receptor for the Agaricus bisporus hemagglutinin, see: J Biol Chem. 1972 Nov 10;247(21):6937-45 |
| BIOACTIVITY | Reacted best towards group A erythrocytes. See:Am J Clin Nutr. 1980 Nov;33(11):2338-45. A. bisporus lectin is a reversible noncytotoxic inhibitor of epithelial cell proliferation which deserves study as a potential agent for cancer therapy. See: Cancer Res 1993 Oct 1;53(19):4627-32 Dietary lectins can alter the proliferation of colonic cells. A normal healthy cell is said to be well differentiated, meaning that its characteristic features and structures are intact. Differentiation is regulated by adhesion molecules which, being glycosylated, are targets for lectin binding. Researchers from Hammersmith Hospital, London, assessed the effects of dietary lectins on the behavior of cancer cells in the colon. See: Gut 1999 May;44(5):709-14 Mushroom (Agaricus bisporus) lectin stimulates insulin release pancreatic islets. Actions are “anti-hyperglycaemic, insulin-releasing and insulin-like.” (J Endocrinol 1998 May;157(2):259-66) Mushroom lectin also improved the hypoglycaemic effect of exogenous insulin, and it’s effects were enhanced by glucose. It is proposed that the specific interaction between mushroom lectin and its receptors may lead to conformational changes in the structure of the membranes of the islet A2- and B-cells that facilitate exocytosis. Effect potentiated by amino acid alanine. |
| SOURCE TISSUE | |
| SPECIFICITY | beta Gal(1-3)GalNAc) |
| INHIBITORS | |
| REFERENCES | J. Biol. Chem., 247, 6937 (1972) |
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