Dr. Peter D'Adamo/ The Blood Type Diets



DR. D'ADAMO: LECSTER 7


The lectin database of Dr. Peter D'Adamo.
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Geodia cydonium

SPECIES IMAGE
SOURCESponge
LECTINS
MOLECULAR IMAGE
CLASS
NOMENLECi.Geo.Cyd.xx.Xga1
INDEXLectin from invertebrates / / / / Gal/GalNAc-binding lectins
CHARACTERIZATION
BIOACTIVITYIn the histochemical system GCA displayed no blood group specificity and labeled red blood cells, the vascular endothelium, and epithelial cells showing blood group antigen expression independent of the ABH blood group status. However, inhibition of GCA reactivity by simple sugars and complex carbohydrate s demonstrated tissue-specific differences of lectin binding related to the ABH blood group status of the tissue and revealed information on the structural requirements of the histological lectin binding site. Tissues that totally lacked blood group antigens or that expressed only the H-antigen disclosed a GCA reactivity which was completely inhibited by lactose. In contrast, tissues that expressed blood group A- or blood group B-antigen exhibited a lactose-resistant lectin binding which was inhibited only by water-soluble blood group substance A from peptone A and by bovine glycophorin but not by other complex carbohydrate s, including human glycophorin and human asialoglycophorin. See: J Histochem Cytochem 1991 Apr;39(4):491-505
SOURCE TISSUE
SPECIFICITYD-galactose
INHIBITORS
REFERENCESEur J Biochem 1983 Jun 15;133(2):263-7
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