Dr. Peter D'Adamo/ The Blood Type Diets



DR. D'ADAMO: LECSTER 7


The lectin database of Dr. Peter D'Adamo.
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Helix pomatia

SPECIES IMAGE
SOURCERoman snail
LECTINSHPA
MOLECULAR IMAGE
CLASS
NOMENLECi.Hel.Pom.xx.Xxxx
INDEXLectin from invertebrates / / / /
CHARACTERIZATIONFor discussion of Helix pomatia isolectins, see: Biochim Biophys Acta 1979 Jul 25;579(1):52-61 For binding of psoriatic skin by HPA, see: Z Hautkr 1986 Sep 1;61(17):1241-9 Helix aspersa also contain the same lectin. See: Z Naturforsch [C]. 1985 Mar-Apr;40(3-4):254-61.
BIOACTIVITYHPA is fairly specific for blood group A antigen. N -acetyl-galactosamine/-glucosamine residues, recognized by HPA, are linked to metastasis in malignant melanoma. In contrast, beta1-6 branched oligosaccharides or sialic acid residues, both of which were correlated with metastasis in other malignancies, are of no functional importance for metastasis formation in malignant melanoma. Thus, HPA proved to be a useful and independent prognostic marker for the metastatic phenotype of melanoma. See: Br J Cancer 2001 Mar 23;84(6):819-23
SOURCE TISSUE
SPECIFICITYTerminal alpha-N-acetyl-D-galactosaminyl
INHIBITORS
REFERENCESUltrastruct Pathol. 1995 Jan-Feb;19(1):51-9.
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