DR. D'ADAMO: LECSTER 7

The lectin database of Dr. Peter D'Adamo.
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Homo sapiens
SPECIES IMAGE
SOURCE
LECTINS	Galectin VII, hGal-7
MOLECULAR IMAGE
CLASS	Proto S-lectin or galectin
NOMEN	GLTh.Hom.Sap.xx.Xxxx
INDEX	Galectin from humans / / / /
CHARACTERIZATION	galectin-7 is a beta-galactoside binding protein specifically expressed in stratified epithelia and notably in epidermis, but barely detectable in epidermal tumors and absent from squamous carcinoma cell lines. galectin-7 was found to be expressed in interfollicular epidermis and in the outer root sheath of the hair follicle, but not in the hair matrix, nor in the sebaceous glands. It was present in esophagus and oral epithelia, cornea, Hassal's corpuscles of the thymus, but not in simple and transitional epithelia. See: Differentiation 1998 Jul;63(3):159-68 galectin-7 can thus be considered as a marker of all subtypes of keratinocytes. See: galectin-7 gene is an early transcriptional target of the tumor suppressor protein P53. See: Nature (London) 1997 (389); 300-305 Also isolated from rat and mouse. galectin-7 is expressed in all cell layers of epidermis and of other stratified epithelia such asthe cornea and the lining of the oesophagus. This suggested that galectin-7 expression might be induced at a particular stage in the embryonic development of stratified epithelia. See: Int J Dev Biol 1999 May;43(3):229-35 The monomeric hGal-7 molecule exists as a dimer in the crystals, but adopts a packing arrangement considerably different from that of Gal-1 and Gal-2, which has implications for carbohydrate recognition. See: Biochemistry 1998 Oct 6;37(40):13930-40
BIOACTIVITY	galectin-7 overexpression is associated with the apoptotic process in UVB-induced sunburn keratinocytes. See: Proc Natl Acad Sci U S A 1999 Sep 28;96(20):11329-34
SOURCE TISSUE
SPECIFICITY	beta-galactoside sugars
INHIBITORS
REFERENCES	Biochemistry, 37, 13930-13940, 1998

DR. D'ADAMO: LECSTER 7

Homo sapiens