DR. D'ADAMO: LECSTER 7

The lectin database of Dr. Peter D'Adamo.
BACK TO INDEX | LECSTER7 FAQ

Homo sapiens
SPECIES IMAGE
SOURCE
LECTINS	L-Selectin (1KJB)
MOLECULAR IMAGE
CLASS	C-lectin
NOMEN	SELh.Hom.Sap.xx.Xxxx
INDEX	/ / / /
CHARACTERIZATION	L-selectin mediates homing of lymphocytes to lymph nodes (LN). Results suggest that the highly vascularized islet carcinomas are shedding tumor cells into the bloodstream in mice, which is a necessary but insufficient condition for metastasis to occur; L-selectin can facilitate homing of such tumor cells to LN, resulting in metastasis. Proc Natl Acad Sci U S A 2001 Mar 27;98(7):3976-81 Selectins mediate macrophage- and dendrocyte-adhesion to lymphocytes activated by signaling through another C-type lectin, the L-selectin, leading to immunoglobulin-mediated responses. Thus, the functional interplay of MBL, galectins and L-selectin in the acute phase response neutralizes the microbial challenge, and lead to further adaptive immunity. See: Dev Comp Immunol 1999 Jun-Jul;23(4-5):401-20
BIOACTIVITY
SOURCE TISSUE
SPECIFICITY	Sulfated forms of sialyl-Le(X) containing Gal-6-SO(4) or GlcNAc-6-SO(4) have been implicated as potential recognition determinants on high endothelial venule ligands for L-selectin. The optimal configuration of sulfate esters on the N-acetyllactosamine (Galbeta1-->4GlcNAc) core of sulfosialyl-Le(X), however, remains unsettled. See: J Biol Chem 2000 Oct 20;275(42):32642-8
INHIBITORS
REFERENCES	Biophys. Res. Commun., 216, 1018-1023, 1995