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DR. D'ADAMO: LECSTER 7The lectin database of Dr. Peter D'Adamo. BACK TO INDEX | LECSTER7 FAQ |
Homo sapiens | |
| SPECIES IMAGE | ![]() | SOURCE |
| LECTINS | Galectin XII |
| MOLECULAR IMAGE | ![]() | CLASS | S-lectin or galectin |
| NOMEN | GLTh.Hom.Sap.xx.Xxxx |
| INDEX | Galectin from humans / / / / |
| CHARACTERIZATION | galectin XII contains two domains that are homologous to the galectin CRD. The N-terminal domain contains all the sequence elements predicted to form the two b-sheets found in other galectins, as well as conserved carbohydrate -interacting residues. The C-terminal domain shows considerable divergence from the consensus sequence and many of these conserved residues are not present. Nevertheless, the protein has lactose-binding activity, most likely due to the contribution of the N-terminal domain. |
| BIOACTIVITY | Ectopic expression of galectin-12 in cancer cells causes cell cycle arrest at the G1 phase and cell growth suppression. See: J Biol Chem 2001 Mar 30 |
| SOURCE TISSUE | |
| SPECIFICITY | beta-galactoside sugars |
| INHIBITORS | |
| REFERENCES | |
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