Dr. Peter D'Adamo/ The Blood Type Diets



DR. D'ADAMO: LECSTER 7


The lectin database of Dr. Peter D'Adamo.
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Homo sapiens

SPECIES IMAGE
SOURCE
LECTINSGalectin VIII
MOLECULAR IMAGE
CLASSTandem Repeat S-lectin or galectin
NOMENGLTh.Hom .Sap.xx.Xxxx
INDEXGalectin from humans / / / /
CHARACTERIZATIONgalectin-8 binding to integrins inhibits cell adhesion and induces apoptosis. It inhibits adhesion of human carcinoma (1299) cells to plates coated with integrin ligands, and induces cell apoptosis. galectin-8 also interacts with other members of the integrin family, like (alpha)(6)(beta)(1 )integrins. In contrast, galectin-8 only minimally interacts with (alpha)(4 )or (beta)(3 )integrins. We propose that galectin-8 is an integrin binding-protein that interacts to a different extent with several, but not all members of the integrin family. Binding of galectin-8 modulates integrin interactions with the extracellular matrix and thus regulates cell adhesion and cell survival. See: J Cell Sci 2000 Jul;113 ( Pt 13):2385-97
BIOACTIVITY
SOURCE TISSUE
SPECIFICITYbeta-galactoside sugars
INHIBITORS
REFERENCES
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