Dr. Peter D'Adamo/ The Blood Type Diets



DR. D'ADAMO: LECSTER 7


The lectin database of Dr. Peter D'Adamo.
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Homo sapiens

SPECIES IMAGE
SOURCE
LECTINSAlpha-2 / Beta-1 integrin
MOLECULAR IMAGE
CLASSIntegrin A (or I) domain
NOMENINTh.Hom.Sap.xx.Xxxx
INDEX / / / /
CHARACTERIZATIONAlpha2/beta1 is a receptor for collagen-I to VI, laminin and possibly fibronectin. It is expressed on B and T lymphocytes, platelets, fibroblasts, endothelial cells and melanoma cells. This receptor is also known as VLA-2 (very late activation antigen 2), GPIa-IIa (glycoprotein Ia-IIa on platelets) and ECMRII (extracellular matrix receptor II) See: http://www.rcsb.org/pdb/cgi/explore.cgi?pdbId=1aox Integrin a2b1 is a cell surface adhesion receptor for collagen and the human pathogen echovirus-1. Integrin alpha 2 beta 1 is a positive regulator of collagenase (MMP-1) and collagen alpha 1(I) gene expression. See: J Biol Chem. 1995 Jun 2;270(22):13548-52
BIOACTIVITY
SOURCE TISSUE
SPECIFICITY
INHIBITORS
REFERENCESJ Biol Chem 272 pp. 28512 (1997)
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