Dr. Peter D'Adamo/ The Blood Type Diets



DR. D'ADAMO: LECSTER 7


The lectin database of Dr. Peter D'Adamo.
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Homo sapiens

SPECIES IMAGE
SOURCE
LECTINSAlpha-E / Beta-7
MOLECULAR IMAGE
CLASSIntegrin
NOMENINTh.Hom.Sap.xx.Xxxx
INDEX / / / /
CHARACTERIZATIONThe P7 integrins alpha4beta7 and alphaEbeta7 play a central role in chronic inflammation, mediating the trafficking, entry, and/or adhesion of lymphocytes in the inflamed pancreas and gut, and their ligands MAdCAM-1, VCAM-1 and E-cadherin are expressed on brain endothelial cells and/or on microvessels in the inflamed central nervous system. alpha4beta1, alpha4beta7, and alphaEbeta7 integrins may all play a contributory role in the progression of chronic forms of demyelinating disease, and together with their ligands could represent potential targets for improved treatment of some forms of multiple sclerosis. See: J Neuroimmunol 2000 Mar 1;103(2):146-52 There was enhanced expression of E-selectin, CLA, LFA-1, ICAM-1, VLA-4, VCAM-1, and alphaEbeta7 in psoriatic lesions versus nonlesional skin. See: Lab Invest 2001 Mar;81(3):335-47
BIOACTIVITY
SOURCE TISSUE
SPECIFICITY
INHIBITORS
REFERENCES
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