Dr. Peter D'Adamo/ The Blood Type Diets



DR. D'ADAMO: LECSTER 7


The lectin database of Dr. Peter D'Adamo.
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Homo sapiens

SPECIES IMAGE
SOURCE
LECTINSMucosal addressin cell adhesion molecule-1 (MADCAM-1)
MOLECULAR IMAGE
CLASSAddressin
NOMENLECh.Xxx.Xxx.xx.Xxxx
INDEXLectin from humans / / / /
CHARACTERIZATIONMucosal addressin cell adhesion molecule-1 (MAdCAM-1) is an adhesion molecule that mediates recruitment of lymphocytes into the gut mucosa. One study in mice demonstrated that anti-MAdCAM-1 antibody significantly ameliorates DSS-induced colitis, suggesting that MAdCAM-1 may be useful for control of inflammatory bowel diseases. See: J Pharmacol Exp Ther 2000 Oct;295(1):183-9 MAdCAM-1 expressed in chronic inflammatory liver disease supports mucosal lymphocyte adhesion to hepatic endothelium. MAdCAM-1 on hepatic vessels supported adhesion of alpha4beta7+ lymphocytes (i.e., gut-derived T cells) from patients with inflammatory bowel disease and primary sclerosing cholangitis, providing a mechanism to explain the hepatic recruitment of mucosal lymphocytes in inflammatory liver disease complicating inflammatory bowel disease. See: Hepatology 2001 May;33(5):1065-72
BIOACTIVITY
SOURCE TISSUE
SPECIFICITY
INHIBITORSSeveral phenylalanine based inhibitors were synthesized as antagonists of the leukocyte cell adhesion process that is mediated through the interactions of the mucosal addressin cell adhesion molecule (MAdCAM) and the integrin alpha4beta7. Analogues 20, 2
REFERENCES
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