DR. D'ADAMO: LECSTER 7

The lectin database of Dr. Peter D'Adamo.
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Homo sapiens
SPECIES IMAGE
SOURCE
LECTINS	Annexin VII, Synexin
MOLECULAR IMAGE
CLASS
NOMEN	ANNh.Hom.Sap.xx.Xxx7
INDEX	/ / / /
CHARACTERIZATION
BIOACTIVITY	An in vitro study of astrocyte-derived C6 rat glioblastoma cells expressing a GFP tagged annexin VII fusion protein demonstrates a sequential redistribution of the fusion protein in response to rising intracellular Ca2+ concentrations. This indicates a role of annexin VII in the regulation of intracellular Ca(2+)-dependent processes in astroglial cells. See: Neuroreport 2001 May 8;12(6):1139-44 Synexin (annexin VII), a Ca(2+)-dependent phospholipid binding protein, may have a role in surfactant secretion, since it promotes membrane fusion between isolated lamellar bodies (the surfactant-containing organelles) and plasma membranes. Am J Physiol Lung Cell Mol Physiol 2001 May;280(5):L991-8 The ANX7 gene is located on human chromosome 10q21, a site long hypothesized to harbor a tumor suppressor gene(s) (TSG) associated with prostate and other cancers. Consistently, analysis of ANX7 protein expression in human prostate tumor microarrays reveals a significantly higher rate of loss of ANX7 expression in metastatic and local recurrences of hormone refractory prostate cancer as compared with primary tumors (P = 0.0001). See: Proc Natl Acad Sci U S A 2001 Apr 10;98(8):4575-80
SOURCE TISSUE
SPECIFICITY
INHIBITORS
REFERENCES	Bioessays. 2001 Feb;23(2):170-8. Review.