Dr. Peter D'Adamo/ The Blood Type Diets



DR. D'ADAMO: LECSTER 7


The lectin database of Dr. Peter D'Adamo.
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Lens culinaris

SPECIES IMAGE
SOURCELentils
LECTINSLCA, LcH
MOLECULAR IMAGE
CLASSLegume lectins
NOMENLECp.Len.Cul.se.Hmg1
INDEXPlant lectin / Plant / Seed / Hololectins / Mannose/glucose-binding lectins
CHARACTERIZATIONFor further characterization of monoclonal antibody 6,F-8 reacting with Lathyrus, Lens and Pisum lectins, see: FEBS Lett. 1989 Apr 10;247(1):77-80. LcH is closely related to the other two-chain mannose/glucose specific legum electins from Vicia species and Lathyrus species.
BIOACTIVITYLcH agglutinates human and rabbit erythrocytes. LcH is a mitogen. See: J Biol Chem 1971 (246); 1590-1595 Lens lectin agglutinates human group A erythrocytes at a titer of 1:4; group B erythrocytes at a titer of 1:4; group B erythrocytes at a titer of 1:4 by crude lectin preparations (16mg/ml). See: Int J Cancer 1970;6:283 Lens lectin has been shown to inhibit graft-versus-host reactions without supressing hematopoetic stem cells in mice. See: Immunobiologia 1986 (173); 35-40
SOURCE TISSUESeed
SPECIFICITYMan/Glc (Man>Glc>Glc>GlcNAc) fucose is apparently an important determinant in the carbohydrate binding specificity of Lens lectin. See: J Biol Chem 1981 (256); 6633-6640
INHIBITORS
REFERENCESBiochemistry. 1969 Jun;8(6):2436-41
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