DR. D'ADAMO: LECSTER 7

The lectin database of Dr. Peter D'Adamo.
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Maackia amurensis
SPECIES IMAGE
SOURCE
LECTINS	MALb, MAHb, MAL, MAHs
MOLECULAR IMAGE
CLASS	Legume lectins
NOMEN	LECp.Maa.Amu.se.Hsi1 (MAHs, MAH) LECp.Maa.Amu.se.Hsi2 (MAHs, MAH) LECp.Maa.Amu.ba.Hsi1 (MAHb) LECp.Maa.Amu.ba.Hsi1 (MALb)
INDEX	Plant lectin / Plant / Seed / Hololectins / Sialic acid-binding lectins
CHARACTERIZATION	There are sialic acid-specific leukoagglutinating lectin from the seeds of Maackia amurensis. Maackia has a strong hemagglutininating lectin, called MAH (M. amurensis hemagglutinin) and a potent mitogenic lectin, called MAL (M. amurensis leucoagglutinin).
BIOACTIVITY	Both MAH and MAL agglutinate human erythrocytes in a blood group independent manner. See: J Biol Chem 1974 (249); 2786-2792 MAH is a more potent agglutinin than MAL. Both lectins are mitogenic toward human periferal lymphocytes, but MAL is fivefold more active than MAH. See: J Biol Chem 1974 (249); 2786-2792 MAL stongly agglutinates the murine lymphoma cell line BW5147. See: J Biol Chem 1988 (261);4576-4585 Maackia lectin discriminates between normal and chronic leukemic human erythrocytes. It bind to normal, but not malignat cells. See: Biochem Biophys Res Comm 1995 (209); 921-929
SOURCE TISSUE	Seed
SPECIFICITY	MAHs: NANA (Ser/Thr-linked tetrasaccharide) MALs: Results indicate that MAL reacts with greatest affinity with the trisaccharide sequence Neu5Ac/Gc alpha 2,3Gal beta 1,4GlcNAc/Glc. MAHb: NANA MALb: NANA
INHIBITORS
REFERENCES	Glycoconj J 1997 Jun;14(4):449-56 J Biol Chem 1991 Jan 5;266(1):83-8