DR. D'ADAMO: LECSTER 7

The lectin database of Dr. Peter D'Adamo.
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Phaseolus limenesis
SPECIES IMAGE
SOURCE	Lima bean
LECTINS	PLA, LBA, LBL
MOLECULAR IMAGE
CLASS	Legume lectins
NOMEN	LECp.Pha.Lim.se.Hga1
INDEX	Plant lectin / Plant / Seed / Hololectins / Gal/GalNAc-binding lectins
CHARACTERIZATION	For isolation, characterization, and interaction with type A blood-group substance, see: Biochemistry. 1972 Oct 10;11(21):3976-84
BIOACTIVITY	Blood group A; at agglutination titer of 1:128 by crude lectin preparation (16mg/ml). See: Int J Cancer 1970;6:283 The lima bean lectin exhibits blood group specificity towards human type A erythrocytes. See: FEBS Letters 1970 (9); 197-201 The lima bean lectin is mitogenic for T- but not B-lymphocytes. The lectin LBL, is much more active than the lectin LBL4 as a mitogen for normal lymphocytes. The lectin LBL, also stimulates mitogenesis in leukaernic lymphocytes whereas LBL4 has minimal activity on these cells. See: Proc Nat Acad Sci 1974 (71); 1848-1851 Oral administration of the lima bean lectin to rats severely retarded the growth of the animals. See: Toxicon 1972 (10);89-91
SOURCE TISSUE	Seed
SPECIFICITY	GalNAc(GalNAc alpha(1,3)[Fuc alpha(1,2)] Gal>alpha-GalNAc>alpha-Gal; Blood group A)
INHIBITORS
REFERENCES