Dr. Peter D'Adamo/ The Blood Type Diets



DR. D'ADAMO: LECSTER 7


The lectin database of Dr. Peter D'Adamo.
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Rana catesbeiana ovum lectin

SPECIES IMAGE
SOURCEFrog eggs
LECTINScSBL
MOLECULAR IMAGE
CLASSLectins Displaying RNase Activity (Leczymes)
NOMENLECa.Ran.Cat.xx.Xxxx
INDEXLectin from higher animal, typically vertebrates / / / /
CHARACTERIZATIONLectin isolated from Rana catesbeiana eggs preferentially agglutinates a large variety of human and animal tumor cells but not normal red blood cells, lymphocytes, or fibroblasts. The phenomenon correlates with a higher binding activity of the lectin with tumor cells. The lectin-dependent tumor cell agglutination is due to a high density of sialic acid at the cell surface
BIOACTIVITYTwo sialic acid-binding lectins, isolated from eggs of Rana catesbeiana (cSBL) and R. japonica (jSBL), agglutinate a large variety of tumor cells, but do not agglutinate normal red blood cells and fibroblasts.
SOURCE TISSUE
SPECIFICITY
INHIBITORSThis agglutinating activity is inhibited by sialoglycoproteins and gangliosides. Treatment of tumor cells with sialidase greatly reduced the lectin-dependent agglutination, and the sialidase-dependent reduction of tumor cell agglutination was inhibited by
REFERENCESCancer Res 1987 Sep 15;47(18):4877-83 Biochem Biophys Res Commun 1991 Jul 15;178(1):407-13
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