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Group O Non-Secretors and Asthma

ABO/Secretor genetic complex and susceptibility to asthma in childhood.

Eur Respir J 2001 Jun;17(6):1236-8

Ronchetti F, Villa MP, Ronchetti R, Bonci E, Latini L, Pascone R, Bottini N, Gloria-Bottini F.

A positive association has recently been reported in adult subjects between O/nonSecretor phenotype and asthma. To confirm this association, this study investigated the joint ABO/Secretor phenotype in a cohort of 165 asthmatic children. Three-hundred and sixty-two consecutive newborn infants from the same population were also studied as controls. The proportion of O/nonSecretor in asthmatic children was higher than in controls, thus confirming the association found in adults. The association was more marked in males than in females. In males, the pattern of association between the joint ABO/Secretor phenotype and asthma is dependent on the age at on-set of symptoms. Since the oligosaccharide composition of cell membrane and mucosal secretions is controlled by the cooperative interaction of ABO and Secretor genes, and since such composition influences the adhesion of infectious agents, the age pattern could reflect a more general interaction between developmental maturation and oligosaccharide structure concerning their effects on susceptibility to viral and bacterial agents.

This study supports my own observations that asthmatics (especially childhood asthmatics) have a higher incidence and severity of asthma. Probably the best long-term strategy is the O-non secretor diet, with its low-lectin elements.

The Ask Dr. D'Adamo internet advice column ran from 1996 to 2009, at which time Dr. D'Adamo's teaching and programming responsibilities no longer allowed him to devote time and resources to directly answering visitor questions. However we've recently reorganized this treasure-trove of material and made it again available to his readership. He occasionally posts new entries. These are marked with a NEW tag.

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