Importance of Secretor Status
In his book Eat Right 4 Your Type, Dr. D'Adamo first introduced readers to the concept of Secretors/Non-secretors. By now you are familiar with the concept that your ABO blood type is controlled by your genetics. The gene coding for your blood type lies on chromosome 9q34. However, a separate gene (called FUT2) actually interacts with your blood type gene, and determine your ability to secrete your blood type antigens into body fluids and tissues.
In the genetics of the secretor system two options exist. A person can be either a Secretor or a Non-secretor. This is completely independent of whether you are a blood type A, B, AB, or O. This means that someone can be an A Secretor or an A Non-secretor, a B Secretor or a B Non-secretor etc.
A Secretor is defined as a person who secretes their blood type antigens into body fluids and secretions like the saliva in your mouth, the mucus in your digestive tract and respiratory cavities, etc. Basically what this means is that a secretor puts their blood type into these body fluids. A Non-secretor on the other hand puts little to none of their blood type into these same fluids. As a general rule, in the U.S. about 20% of the population are Non-secretors (with the remaining 80% being Secretors).
Advantages and Disadvantages:
With respect to the ABO blood types, it is very difficult to state that one type is more advantageous than another. Each blood type has its own strengths and characteristic weaknesses. However, this does not appear to be the case with the Secretor gene. As a generality, being a Non-secretor (based on all of the available information) does actually appear to be a potential health disadvantage. At a very basic level, being able to secrete blood type into your saliva, mucus, etc. allows for an added degree of protection against the environment, particularly with respect to microorganisms and lectins.
Similar to the ABO blood types, it appears additional genetic information must be linked to the Secretor gene, because predictable trends in non-blood type aspects of physiology have a close association with Secretor/Non-secretor status. Aspects of physiology such as the relative activity of an enzyme called intestinal alkaline phosphatase; propensities toward clotting, reliability of some tumor markers, and generalized performance of your immune system have predictable trends depending upon your Secretor status.
As a general rule, a higher intensity of oral disease is found among Non-secretors. This includes dysplasia (precancerous changes to the tissue) and an increase in cavities. Statistically speaking, blood type A Secretors have the lowest number of cavities.
With regards to aspects of lung function, being a Non-secretor takes its usual place as a health disadvantage. Several researchers have suggested that being a Non-secretor might predispose an individual to damaging effects, while being a secretor might add a degree of protection against harmful environmental assaults to our lungs.
Non-secretors appear to have an increase in the prevalence of a variety of autoimmune diseases including ankylosing spondylitis, reactive arthritis, psoriatic arthropathy, Sjogren's syndrome, multiple schlerosis, and Grave's disease.
Non-secretors are at a greater risk of developing diabetes (especially adult onset diabetes); and they might be at a greater risk of developing complications from diabetes. Data allows the conclusion that Non-secretors are a risk factor for myocardial infarction and heart disease (note: this is particularly true for men).
Alcoholism has been associated with the Non-secretor blood type. On the positive side, alcohol consumption appears to exert a protective effect on lung function and to lower the risk of heart disease more in Non-secretors than in Secretors. The key principle with the use of alcohol is for Non-secretors (and everybody actually) is moderation.
Non-secretors are at a greater risk for recurrent UTI's, have a greater tendency to increased inflammation, and are much more likely to develop renal scars. Being a blood type Secretor on the other hand offers a degree of protection; cutting your risk of recurrent UTI's by greater than 50% and dramatically decreasing the likelihood you will have renal scars develop.
Based upon this tendency of Non-secretor saliva to not only fail to prevent attachment of Candida., but maybe actually promote the binding of Candida to your tissue, we would expect that research would show higher tendency to Candida problems among Non-secretors. This is what we find to be true. Non-secretors are much more likely to be carriers of Candida and to have problems with persistent infections. Blood type O Non-secretors might be the most affected of the Non-secretor blood types, since Candida also appears to have an easier time colonizing (attaching to) the blood type O antigen.
Secretors are known to have higher levels
of IgG and IgA antibodies. The lack of IgA antibodies perhaps explains the
link between non-secretor status and an increased frequency of heart valve
problems secondary to bacteria infection. Because IgA functions much like
the way a rampart or palisade wall protects a town from invasion, most if
not all non-secretors have problems with gut permiability ("leaky
I hope you can begin to appreciate that having information about your Secretor/Non-secretor status might be a valuable piece of health information. While, unfortunately, the news for Non-secretors is not as positive, it is better to have information. With information comes knowledge. And with knowledge, comes the ability to intervene.
Dr. D'Adamo has done blood testing for Secretor/Non-secretor status for years. Now, through an arrangement he has made with a lab, you can order a genomic test kit to determine your Secretor/Non-secretor status. The test will need to be returned to the lab for results to be obtained. .
Look for further information on Secretor/Non-secretor blood type connection in his book
Live Right 4 Your Type. In addition to allowing important diet refinements, knowing your secretor status can help you use nutritional supplements more effectively and intelligently while adding to your awareness of illness and metabolic dysfunction you may be prone to because of your secretor genetics.
Knowing your secretor type empowers you to further refine your Blood Type Diet and take strategic control of your own wellness and lifestyle choices.
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