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Questions About Lectins

Bean Mushroom Lectins For HIV


STUDY:
Examination of lectins, polysaccharopeptide, polysaccharide, alkaloid, coumarin and trypsin inhibitors for inhibitory activity against human immunodeficiency virus reverse transcriptase and glycohydrolases.

JOURNAL:
Planta Med 2001 Oct;67(7):669-72

AUTHORS:
Wang HX, Ng TB.

ABSTRACT:
A variety of lectins were tested in vitro for inhibitory action against the activities of human immunodeficiency virus type 1 (HIV-1) reverse transcriptase and the N-glycohydrolases (alpha-glucosidase, beta-glucosidase and beta-glucuronidase). Lectins from Phaseolus vulgaris, Momordica charantia, Ricinus communis and its constituent chains, and Agaricus bisporus were able to inhibit HIV-1 reverse transcriptase. P. vulgaris lectin and A. bisporus lectin were the most potent.


COMMENTARY:
The tested lectins included red kidney beans (Phaseolus vulgaris), Chinese Bitter Melon (Momordica charantia), Castor Bean (Ricinus communis) and the common mushroom (Agaricus bisporus). Castor bean lectin is too toxic for use. Bitter Melon has been extensively analyzed and shows some anti-HIV promise. However, it appears that kidney beans and common mushroom may have an even better ability to inhibit the enzyme reverse transcriptase (which is a critical part of the HIV reproductive cycle.)

Certainly, the addition of either food (depending on ABO status) in the regular diet of any HIV positive person can offer a potentially safe, inexpensive and tasty way to help block the virus.








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