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Blood Groups and Heart Attack

A study of relationship of ABO blood groups with myocardial infarction and angina pectoris.

J Ayub Med Coll Abbottabad 2001 Oct-Dec;13(4):25-6

Akhund IA, Alvi IA, Ansari AK, Mughal MA, Akhund AA.

BACKGROUND: This is a comprehensive report that has determined the occurrence of Myocardial infarction and Angina pectoris in "ABO" blood group system among patients with coronary artery disease in some areas of Sindh province of Pakistan. METHODS: Three hundred patients with Coronary Disease (CAD) were selected from cardiology wards of LMC hospital Hyderabad, DMC hospital Karachi and PMC hospital Nawabshah. The patients were separated into two categories: myocardial infarction and angina pectoris. The patients with old myocardial infarction were also included. A careful history was taken, suggesting myocardial infarction (MI) or angina from a standard WHO (Rose) chest pain, and a electrocardiogram showing evidence of possible myocardial infarction and angina, and the patient's recall of a doctor's diagnosis of M.I or angina. ABO blood grouping of above patients was done by simple agglutination method. RESULTS: The blood group "A" was the commonest among myocardial infarction and angina pectoris patients while these diseases were least in blood group "O" patients. CONCLUSIONS: This comparison shows the existence of a direct relation between blood group antigens and coronary artery disease. It is therefore of great importance for future genetic studies, as present report and our previous studies give clear picture of excess and deficit of CAD in particular blood groups of "ABO" system. This may be due to some special genetic makeup.

Despite protestations from Dean Ornish to the contrary*, numerous studies (many harking back to the 1950's) have linked ABO type to higher levels of cholesterol and coronary artery disease. This study again demonstrates the power of defining diet by blood group: By using this system, you eat not just for today, but for tomorrow. If you are type A, you'll want to take the advice of the 'broad-band paleo-dieters' with less than a grain of salt.

* Which I find odd, since ABO blood group was linked to heart disease in the famous Framingham Heart Studies of the 60-s and 70's -the same studies which documented a link between heart diease and cholesterol, and cited so frequently by Dr. Ornish. Selective attention?

The Ask Dr. D'Adamo internet advice column ran from 1996 to 2009, at which time Dr. D'Adamo's teaching and programming responsibilities no longer allowed him to devote time and resources to directly answering visitor questions. However we've recently reorganized this treasure-trove of material and made it again available to his readership. He occasionally posts new entries. These are marked with a NEW tag.

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