A rush is on to understand what underpins the progression of Covid-19 from a mild flu-like presentation, to out-of-control pneumonia, and ultimately, system-wide collapse. We know some factors (comorbidities) that tend to increase the risk of severe consequences of Covid-19, such as age, gender, high blood pressure, and even ABO blood type. In addition, severe
Angiotensin-converting enzyme 2 (ACE2), a protein on the surface of the cell membrane, is now at center-stage in this outbreak as the key receptor for the spike glycoprotein of SARS-CoV-2. ACE2 is part of renin–angiotensin–aldosterone system (RAAS) is an elegant cascade of protein linkages that orchestrate key processes in human physiology by affecting the diameter
I’ve been building a database of potential agents (drugs, botanical, supplements and foods) that have some evidence basis behind their use as antivirals against the novel coronavirus. The online database can be accessed here.
Some pretty pictures of detoxification network analysis courtesy of an app I’m developing called ‘Rheingold,’ which takes drug/ supplement/ food queries and returns predicted cytochrome consequences. In addition, with this client I was able to superimpose their Opus23 genomic data, and as can be seen in the image, the red box for CYP2D6 shows a
I’ve been exploring artificial intelligence (AI) modules from the Comprehensive Perl Archive Network (CPAN), a great resource for legally stealing very useful tools made by people far smarter than me. One of their featured machine learning modules is also one of the simplest. It’s called the ‘Naive Bayes’ algorithm. I like simple, so I started
The UB/COEGM Pathfinder Scholarship Program is a partnership between the University of Bridgeport School of Health Sciences and the Center of Excellence in Generative Medicine. Its mission is to groom developing physicians in the skills of twenty-first century precision medicine through the use of bioinformatics. It’s been my honor and privilege to act as a